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Welcome to visit the database for target genes of lncRNAs in Human and Mouse

Introduction:

Long noncoding RNAs (lncRNAs) have been emerged as critical regulators of gene expression at epigenetic, transcriptional and post-transcriptional level, yet which genes are regulated by lncRNAs remains to be characterized. To assess the effects of a specific lncRNA on gene expression, increasing researchers profiled gene expression level changes after knocking down and overexpressing the lncRNA, or conducting the lncRNA binding experiments by immunoprecipitation assays, pull down arrays and luciferase reporter assays. However, no online repository is currently available to collect these lncRNA-target relationships.

To make it convenient for researchers to know the relationship between lncRNA and their targets, we develop this database to provide a comprehensive resource of lncRNA-target relationships inferred from low-throughput experiments or lncRNA knockdown or overexpression experiments followed by microarray/RNA-seq.

In the previous version of LncRNA2Target (v1.0), Target genes of a lncRNA are defined as the differentially expressed genes after knocking down or overexpressing the lncRNA. While lncRNA2Target V2.0 collects more lncRNA-Target relationships from more experimental methods. By reviewing all published lncRNA papers, we manually curated the lncRNA-target relationships confirmed by immunoprecipitation assays, RNA pull-down assays and luciferase reporter assays. We also identified all the differentially expressed target genes from the microarray and RNA-seq data after knocking down or overexpressing a lncRNA.

Currently, users can
• Obtain the target genes regulated by a lncRNA by searching the lncRNA gene ID or symbol.
• Obtain the regulatory lncRNAs of a specific target gene by searching the target gene ID or symbol.
• Download all manually curated lncRNA-target association data.
• Submit information of lncRNA-target relationship to the LncRNA2Target database.

Statistics:

Target genes of lncRNA validated by immunoprecipitation assays, RNA pull down assays or luciferase reporter assays, or differentially expressed genes (potential targets of a lncRNA) inferred from the lncRNA knockdown or overexpression followed by RT-qPCR or western blot.

No. of lncRNAs No. of target genes No. of lncRNA-target associations
Human 356 689 1,465
Mouse 81 188 210

Differentially expressed genes (potential targets of a lncRNA) inferred from the lncRNA knockdown or overexpression followed by microarray or RNA-seq.

No. of lncRNAs No. of target genes No. of lncRNA-target associations
Human 61 28,865 72,102
Mouse 134 19,973 78,360

Release & Version Information:

June 20, 2018, the LncRNA2Target database v2.0 was released.

Contact:

Qinghua Jiang, professor
Center for Bioinformatics
School of Life Science and Technology
Harbin Institute of Technology, Harbin 150001, China
Mail: qhjiang@hit.edu.cn